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Vijayalakshmi, A.
- Free Radical Scavenging Activity of Scindapsus officinalis Fruits
Authors
1 Dept. of Pharmacognosy, Vels College of Pharmacy, Pallavaram, Chennai-600 117, IN
2 Department of Pharmacognosy, Vels College of Pharmacy, Pallavaram, Chennai-600 117, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 4 (2010), Pagination: 280-283Abstract
In the present study, coarse powder of Scindapsus officinalis (Roxb.) Schott. fruit was extracted successively using hexane, chloroform, ethyl acetate and 50% ethanol. The ethyl acetate and 50% ethanolic extracts were investigated for its antioxidant activity by using nitric oxide and DPPH radical scavenging methods. The IC50 value was also calculated. Ascorbic acid was used as a standard. Both 50% ethanolic and ethyl acetate extract were found to exert concentration dependent free radical scavenging activity but former extract was more effective than the later on. The highest free radical scavenging activity by Scindapsus officinalis fruit extracts was observed at concentration of 1000 μg/ml.Keywords
Scindapsus officinalis (Roxb.) Schott., Antioxidant, Free Radicals, IC50 Value.
- Antidepressant-Like Effects of the Ethanolic Extract of Albizzia lebbeck (Linn) Leaves in Animal Models of Depression
Authors
1 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai–117, Tamil Nadu, IN
2 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, IN
3 Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamilnadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 30-33Abstract
The present study was designed to investigate the antidepressant effects of Albizzia lebbeck leaves in various animal depression models. The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck leaves (200 and 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/kg. p.o) and fluoxetine (20mg/kg.p.o). The leaf extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST.
The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Our results suggested that the ethanolic extract of Albizzia lebbeck leaves exerts antidepressant-like effect.